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Solid tumor models for the assessment of different treatment modalities: I. Radiation-induced changes in growth rate characteristics of a solid tumor model.

机译：用于评估不同治疗方式的实体瘤模型：I.辐射诱发的实体瘤模型生长速率特征的变化。

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摘要

A computer program has been developed to quantitatively evaluate changes in tumor growth rates of a solid tumor model (hepatoma 3924A) after a series of radiation doses from 375 R to 3750 R. The computer-derived growth curves are simulated from the volumes of the individual tumors rather than from the mean tumor volume at any specific time point after treatment. The ability to generate data from a family of tumor growth curves permits a more precise evaluation of therapeutic effects on tumors than can be obtained with conventional methods. The quantitative determination of equivalent amounts of radiation needed to produce comparable 5-fluorouracil-induced changes in tumor growth rate has been made. The ability to determine quantitatively radiotherapeutic and chemotherapy equivalents on these solid tumor models has direct implications in regard to our effort to improve the treatment of cancer. At present no specific solid tumor or groups of solid tumors have provided all of the necessary information for clinical utilization in therapeutic scheduling of different forms of cancer treatment. Since solid tumors comprise the majority of human cancer, one of the primary objectives of these studies has been the establishment of a solid tumor model that could serve both as a system for devising improved therapeutic scheduling and for a better understanding of solid tumors.
机译：已经开发了一种计算机程序来定量评估一系列放射剂量从375 R到3750 R后实体肿瘤模型（肝癌3924A）的肿瘤生长速率的变化。计算机衍生的生长曲线是根据个体的体积进行模拟的肿瘤，而不是治疗后任何特定时间点的平均肿瘤体积。从肿瘤生长曲线族产生数据的能力允许比常规方法获得的对肿瘤治疗效果的更精确的评估。进行了确定可比的5-氟尿嘧啶诱导的肿瘤生长变化所需的辐射当量的定量测定。在这些实体瘤模型上定量确定放射疗法和化学疗法当量的能力，对我们改善癌症治疗的努力具有直接的意义。目前，没有特定的实体瘤或实体瘤组提供了所有必要的信息，以供临床应用在不同形式的癌症治疗的治疗计划中。由于实体瘤占人类癌症的大多数，因此这些研究的主要目的之一是建立实体瘤模型，该模型既可以用作设计改进的治疗方案的系统，又可以更好地理解实体瘤。

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